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KMID : 0387420080190030085
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 3 p.85 ~ p.100
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The Effects of kagamSinKiHwan(KSKH) Hot water extract & ultra-fine Powder on Proinflammatory cytokine of Microglia & Memory Deficit of Amnesia Mice Model
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Lim Hyeon-Joo
Jung In-Chul
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Abstract
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Objective: This experiment was designed to investigate the effect of the KSKH hot water extract & ultra-fine powder on microglia and memory deficit model.
Method: The effects of the KSKH hot water extract on expression of IL-1, IL-6, TNF- mRNA and production of IL-1, IL-6, TNF- in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the KSKH hot water extract & ultra-fine-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated.
Results: 1. The KSKH hot water extract suppressed the expression of IL-1, IL-6, TNF- mRNA in BV2 microglial cell line treated by LPS. 2. The KSKH hot water extract suppressed the production of IL-1, IL-6, TNF- in 100 concentration of BV2 microglial cell line culture supernatant. 3. The KSKH hot water extract & ultra-fine powder decreased AChE activation significantly in the serum of the memory deficit mice induced by scopolamine. 4. The KSKH hot water extract & ultra-fine powder showed significant effect on memory impairment in the stop-through latency type of Morris water maze test.
Conclusions: This experiment shows that the KSKH hot water extract & ultra-fine powder might be effective for the prevention and treatment of amnesia and Alzheimer’s disease. Investigation into the clinical use of the KSKH hot water extract & ultra-fine powder for amnesia and Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, Amnesia, Microglia, KagamSinKiHwan(KSKH), Hot water extract & ultra-fine powder
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